HCID 9881809、化合物 → Methyl 3-(3-cyanophenyl)-5-(formyl)benzoate

HRID 1862571ノート

反応式

HRID 1862571 の反応式
[C:1]([C:3]1[CH:4]=[C:5]([C:9]2[CH:10]=[C:11]([CH:16]=[C:17]([CH2:19][OH:20])[CH:18]=2)[C:12]([O:14][CH3:15])=[O:13])[CH:6]=[CH:7][CH:8]=1)#[N:2]>ClCCl.[O-2].[O-2].[Mn+4]>[C:1]([C:3]1[CH:4]=[C:5]([C:9]2[CH:10]=[C:11]([CH:16]=[C:17]([CH:19]=[O:20])[CH:18]=2)[C:12]([O:14][CH3:15])=[O:13])[CH:6]=[CH:7][CH:8]=1)#[N:2]

参加物

4

反応物 1

HCID 9881809HCID 9881809、化合物

生成物 1

HCID 9795280Methyl 3-(3-cyanophenyl)-5-(formyl)benzoate収率 85.2%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

In 200 ml of dichloromethane, was dissolved 9.05 g of the compound obtained in Example 1, 2 or 3. To the resulting solution, was added 20.6 g of manganese dioxide. The obtained mixture was stirred at room temperature for 40 hours. The reaction solution was filtered through Celite, and the Celite was further washed with dichloromethane. Each filtrate was combined into one portion, and the solvent was removed under reduced pressure to afford 7.65 g (85%) of the title compound as a white crystal.

後処理

  1. filtrationThe reaction solution was filtered through Celite
  2. washthe Celite was further washed with dichloromethane
  3. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-5445b772c26a4715a503bcd52140ff90
出典データセット
uspto-grants-2003_03
特許番号
US06538137B1

反応ノート

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