Ammonia → 2-[3-Methoxy-4-(3-phenyl-propoxy)-phenyl]-ethylamine
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:19][C:20]#[N:21])[CH:6]=[CH:7][C:8]=1[O:9][CH2:10][C:11]#[C:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.N>CO.[Ni]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:19][CH2:20][NH2:21])[CH:6]=[CH:7][C:8]=1[O:9][CH2:10][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1参加物
5
実験手順
A mixture of [3-methoxy-4-(3-phenyl-prop-2-ynyloxy)-phenyl]-acetonitrile (2.0 g), liquid ammonia (5 g) and Raney-nickel (1 g) in methanol (100 ml) is shaken in an autoclave under hydrogen (100 bar) at +70° C. for 2 hours. The reaction mixture is filtered and evaporated. 2-[3-Methoxy-4-(3-phenyl-propoxy)-phenyl]-ethylamine is obtained as an oil.
後処理
- filtrationThe reaction mixture is filtered
- customevaporated
出典と根拠
- ORDレコード
- ord-b52a415ee6d844c98cf5d47f5f538a9a
- 出典データセット
- uspto-grants-2003_03
- 特許番号
- US06538159B2
反応ノート
読み込み中…