Acetic Anhydride → N-(1,4,5,6-Tetrahydro-5-methyl-4,6-dioxo-2-pyrimidinyl)acetamide

HRID 1862829ノート

反応式

HRID 1862829 の反応式
[NH2:1][C:2]1[NH:3][C:4](=[O:10])[CH:5]([CH3:9])[C:6](=[O:8])[N:7]=1.[C:11](OC(=O)C)(=[O:13])[CH3:12]>C(O)(=O)C>[C:11]([NH:1][C:2]1[NH:7][C:6](=[O:8])[CH:5]([CH3:9])[C:4](=[O:10])[N:3]=1)(=[O:13])[CH3:12]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 27247262-amino-5-methyl-1H-pyrimidine-4,6-dione

生成物 1

HCID 20393810N-(1,4,5,6-Tetrahydro-5-methyl-4,6-dioxo-2-pyrimidinyl)acetamide

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

80 parts of 2-amino-4,6-dioxo-5-methyl-pyrimidine are treated for 8 hours under reflux in a mixture comprising 500 parts by volume of acetic acid and 108 parts by volume of acetic anhydride. 87 parts of the desired product are obtained by filtration, washing with ether and drying in vacuo.

出典と根拠

ORDレコード
ord-d6c4d46621f341e6a7072144e29143c3
出典データセット
uspto-grants-1979_09
特許番号
US04166852

反応ノート

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