化工社化工社 化学情報印刷レポート · 研究参考用
Ethanol → Ipriflavone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Morpholine | HCID 8083 | — |
| 反応物 | Ethylorthoformate | HCID 53630039 | — |
| 反応物 | 2-Hydroxy-4-isopropyloxy-phenyl-benzyl ketone | HCID 54277918 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Ipriflavone | HCID 3747 | — |
反応手順
27 g of 2-hydroxy-4-isopropyloxy-phenyl-benzyl ketone, 22 g of ethyl orthoformate and 5 g of morpholine are boiled for 8 hours in 200 ml of dimethyl formamide. The ethanol formed during the reaction is removed through a fractionation head. Then the major part of solvent is distilled off in a vacuum and the residue is diluted with dilute aqueous hydrochloric acid. The crude product is filtered and recrystallized from acetone, yielding 24 g of 7-isopropyloxy-isoflavone of m.p. 115°-117° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04166862 |
| 出典データセット | uspto-grants-1979_09 |
| ORD ID | ord-be2466a5115b41ddafb27a0ee8c57a74 |
| 出典メモ | uspto-grants-1979_09 |