Potassium Carbonate → 7-[(4-Nitrophenyl)methoxy]-3-phenylchromen-4-one

HRID 1862864ノート

反応式

HRID 1862864 の反応式
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:18])[C:7]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:8][O:9]2)=[CH:4][CH:3]=1.[N+:19]([C:22]1[CH:29]=[CH:28][C:25]([CH2:26]I)=[CH:24][CH:23]=1)([O-:21])=[O:20].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[N+:19]([C:22]1[CH:29]=[CH:28][C:25]([CH2:26][O:1][C:2]2[CH:11]=[C:10]3[C:5]([C:6](=[O:18])[C:7]([C:12]4[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=4)=[CH:8][O:9]3)=[CH:4][CH:3]=2)=[CH:24][CH:23]=1)([O-:21])=[O:20]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 76598alpha-Iodo-p-nitrotolueneHCID 53768917-Hydroxyisoflavone

生成物 1

HCID 15228077-[(4-Nitrophenyl)methoxy]-3-phenylchromen-4-one

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

10.5 g of 7-hydroxy-isoflavone in 200 ml of anhydrous acetone are boiled for 2 hours with 11.8 g of p-nitrobenzyl iodide in the presence of 5.7 g of anhydrous potassium carbonate under reflux condenser. On distilling off about half of the volume of acetone, the residue is poured onto 1000 ml of water. The precipitating crude product is subjected to suction and recrystallized from glacial acetic acid, affording light yellow plates of 7-p-nitrobenzyloxy-isoflavone, m.p. 225°-226° C.

後処理

  1. temperatureunder reflux condenser
  2. distillationOn distilling off about half of the volume of acetone
  3. additionthe residue is poured onto 1000 ml of water
  4. customrecrystallized from glacial acetic acid

出典と根拠

ORDレコード
ord-a61f1c4e9df04bcb8c154ed451741622
出典データセット
uspto-grants-1979_09
特許番号
US04166862

反応ノート

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