4-(Trifluoromethyl)benzenesulfonyl chloride → HCID 20392924、化合物
反応式
[F:1][C:2]([F:35])([F:34])[C:3]1[CH:12]=[C:11]2[C:6]([C:7]([NH:19][C:20]3[CH:33]=[CH:32][C:23]([C:24]([N:26]4[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]4)=[O:25])=[CH:22][CH:21]=3)=[CH:8][C:9](C3C=CC=CC=3)=[N:10]2)=[CH:5][CH:4]=1.[F:36][C:37]([F:49])([F:48])[C:38]1[CH:43]=[CH:42][C:41]([S:44](Cl)(=[O:46])=[O:45])=[CH:40][CH:39]=1>C(N(CC)CC)C>[F:36][C:37]([F:49])([F:48])[C:38]1[CH:43]=[CH:42][C:41]([S:44]([N:29]2[CH2:30][CH2:31][N:26]([C:24](=[O:25])[C:23]3[CH:22]=[CH:21][C:20]([NH:19][C:7]4[C:6]5[C:11](=[CH:12][C:3]([C:2]([F:1])([F:34])[F:35])=[CH:4][CH:5]=5)[N:10]=[CH:9][CH:8]=4)=[CH:33][CH:32]=3)[CH2:27][CH2:28]2)(=[O:46])=[O:45])=[CH:40][CH:39]=1参加物
4
実験手順
In the manner given in Example 15, 4-[4-[[7-(trifluoromethyl)phenyl-4-quinolinyl]amino]benzoyl]piperazine is reacted with p-trifluoromethylphenylsulfonyl chloride in the presence of triethylamine to give 1-[4-(trifluoromethyl)phenylsulfonyl]-4-[4-[[7-(trifluoromethyl)-4-quinolinyl]amino]benzoyl]piperazine.