Water → (p-Chlorophenoxy)[p-(p-chlorophenoxy)phenyl]acetic acid

HRID 1863320ノート

反応式

HRID 1863320 の反応式
[OH-].[K+].[Cl:3][C:4]1[CH:29]=[CH:28][C:7]([O:8][CH:9]([C:14]2[CH:19]=[CH:18][C:17]([O:20][C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=3)=[CH:16][CH:15]=2)[C:10]([O:12]C)=[O:11])=[CH:6][CH:5]=1.O>CO>[Cl:3][C:4]1[CH:29]=[CH:28][C:7]([O:8][CH:9]([C:14]2[CH:15]=[CH:16][C:17]([O:20][C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=3)=[CH:18][CH:19]=2)[C:10]([OH:12])=[O:11])=[CH:6][CH:5]=1

参加物

5

反応物 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 12531843Methyl(p-chlorophenoxy)[p-(p-chlorophenoxy)phenyl]acetate

生成物 1

HCID 12531874(p-Chlorophenoxy)[p-(p-chlorophenoxy)phenyl]acetic acid収率 94.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 10 g of KOH in 80 ml of 50% methanol is added 30.2 g of methyl (p-chlorophenoxy)-[p-(p-chlorophenoxy)phenyl]acetate. The mixture is refluxed for 3 hours, cooled, poured into 100 ml of water. The solution is extracted with two 100-ml portions of ether. The aqueous layer is acidified with concentrated hydrochloric acid. The mixture is extracted with two 100-ml portions of ether and the extracts are washed with water, brine and dried (MgSO4). Evaporation of the solvent yields an oil which is triturated with petroleum ether to give 27.5 g of product as white crystals. Recrystallization from hexane-chloroform gives white plates, mp 141°-142° C.

後処理

  1. temperatureThe mixture is refluxed for 3 hours
  2. temperaturecooled
  3. extractionThe solution is extracted with two 100-ml portions of ether
  4. extractionThe mixture is extracted with two 100-ml portions of ether
  5. washthe extracts are washed with water, brine
  6. dry with materialdried (MgSO4)
  7. customEvaporation of the solvent
  8. customyields an oil which
  9. customis triturated with petroleum ether

出典と根拠

ORDレコード
ord-facb2020291140a78b889f480399fdf3
出典データセット
uspto-grants-1979_09
特許番号
US04168385

反応ノート

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