[5-Methyl-2-(3-methylphenyl)-1H-imidazol-4-yl]methanol → 4-Methyl-2-(3-methylphenyl)-1H-imidazole-5-carboxaldehyde

HRID 1863420ノート

反応式

HRID 1863420 の反応式
[CH3:1][C:2]1[NH:6][C:5]([C:7]2[CH:8]=[C:9]([CH3:13])[CH:10]=[CH:11][CH:12]=2)=[N:4][C:3]=1[CH2:14][OH:15]>[O-2].[O-2].[Mn+4].C(Cl)Cl>[CH3:1][C:2]1[NH:6][C:5]([C:7]2[CH:8]=[C:9]([CH3:13])[CH:10]=[CH:11][CH:12]=2)=[N:4][C:3]=1[CH:14]=[O:15]

参加物

4

反応物 1

HCID 20291433[5-Methyl-2-(3-methylphenyl)-1H-imidazol-4-yl]methanol

生成物 1

HCID 224119984-Methyl-2-(3-methylphenyl)-1H-imidazole-5-carboxaldehyde

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

A mixture of 5-methyl-2-m-tolyl-4-imidazolemethanol (13.0 gm., 0.064 mole), activated manganese dioxide (65 gm.) and methylene chloride (200 ml.) is stirred at room temperature for 20 hours. The reaction mixture is then filtered, the solvent removed in vacuo to afford 9.1 gm. (0.045 mole) of peach-colored solid.

後処理

  1. filtrationThe reaction mixture is then filtered
  2. customthe solvent removed in vacuo
  3. customto afford 9.1 gm

出典と根拠

ORDレコード
ord-b1a6e1542c0f4e1a8aba201cd4ab84df
出典データセット
uspto-grants-1979_09
特許番号
US04168964

反応ノート

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