1H-1,2,4-Triazole, 1-acetyl-3-(p-chlorophenyl)-5-methyl- → 3-(4-Chlorophenyl)-5-methyl-1H-1,2,4-triazole

HRID 1863471ノート

反応式

HRID 1863471 の反応式
C([N:4]1[C:8]([CH3:9])=[N:7][C:6]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=2)=[N:5]1)(=O)C>O>[Cl:16][C:13]1[CH:12]=[CH:11][C:10]([C:6]2[N:7]=[C:8]([CH3:9])[NH:4][N:5]=2)=[CH:15][CH:14]=1

参加物

3

反応物 1

HCID 30504871H-1,2,4-Triazole, 1-acetyl-3-(p-chlorophenyl)-5-methyl-

生成物 1

HCID 124680223-(4-Chlorophenyl)-5-methyl-1H-1,2,4-triazole収率 105.5%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

27 g (114 mM) 1-Acetyl-3-(4-chlorophenyl)-5-methyl-1H-1,2,4-triazole is refluxed in 800 ml of water for 9 hours and stirred overnight at room temperature. The product is filtered out, washed with water, and dried at 90° under vacuum overnight to give 23.4 g of the title compound, m.p. 173°-175°.

後処理

  1. filtrationThe product is filtered out
  2. washwashed with water
  3. customdried at 90° under vacuum overnight

出典と根拠

ORDレコード
ord-ea90009cd2be4930b7e0cb19c898ba60
出典データセット
uspto-grants-1979_09
特許番号
US04169148

反応ノート

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