Sodium periodate → HCID 68524098、化合物

反応式

I([O-])(=O)(=O)=[O:2].[Na+].[F:7][C:8]([F:27])([F:26])[C:9]1[N:10]=[CH:11][C:12]2[CH2:18][CH2:17][N:16]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:15][C:13]=2[N:14]=1>C(OCC)(=O)C.[Ru](=O)=O>[O:2]=[C:15]1[C:13]2[N:14]=[C:9]([C:8]([F:7])([F:26])[F:27])[N:10]=[CH:11][C:12]=2[CH2:18][CH2:17][N:16]1[C:19]([O:21][C:22]([CH3:23])([CH3:24])[CH3:25])=[O:20]

参加物

実験手順

To a mixture of 51 mg (0.328 mmol) of ruthenium dioxide and 25.9 mL (11.9 mmol) of 10% sodium periodate aqueous solution was added a solution of 766 mg (2.53 mmol) of tert-butyl 2-(trifluoromethyl)-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-carboxylate in 20 mL of ethyl acetate. The mixture was stirred vigorously for 4 h and then partitioned between ethyl acetate and water. The aqueous phase was extracted with 2 additional portions of ethyl acetate. The combined organic fractions were concentrated. Flash chromatography of the residue on silica gel (9:1 hexanes/ethyl acetate) afforded material that was collected on a filter and washed with diethyl ether to give the title compound as a white solid. LC-MS 318 (M+1).