Hydrochloric Acid → HCID 68523413、化合物
反応式
[O:1]=[C:2]1[C:7]2[N:8]=[C:9]([C:12]([F:15])([F:14])[F:13])[N:10]=[CH:11][C:6]=2[CH2:5][CH2:4][N:3]1C(OC(C)(C)C)=O.Cl>O1CCOCC1>[F:15][C:12]([F:13])([F:14])[C:9]1[N:10]=[CH:11][C:6]2[CH2:5][CH2:4][NH:3][C:2](=[O:1])[C:7]=2[N:8]=1参加物
4
実験手順
Approximately 485 mg (1.53 mmol) of tert-butyl 8-oxo-2-(trifluoromethyl)-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-carboxylate was treated with 10 mL of 4M HCl in anhydrous dioxane, and the solution was stirred at room temperature for 0.5 h, then concentrated to dryness. The residue was washed with diethyl ether and dried to give the title compound as a white solid. LC-MS 218 (M+1).
後処理
- concentrationconcentrated to dryness
- washThe residue was washed with diethyl ether
- customdried
出典と根拠
- ORDレコード
- ord-03cd092c21e3479c8be45433c6e5e74e
- 出典データセット
- uspto-grants-2009_12
- 特許番号
- US07625888B2
反応ノート
読み込み中…