Hydrochloric Acid → HCID 87483712、化合物

HRID 1863952ノート

反応式

HRID 1863952 の反応式
C(OC(=O)[NH:7][C@H:8]([CH2:27][C:28]1[CH:33]=[C:32]([F:34])[C:31]([F:35])=[CH:30][C:29]=1[F:36])[CH2:9][C:10]1[N:14]2[CH2:15][CH2:16][C:17]3[C:18](=[N:19][C:20]([C:23]([F:26])([F:25])[F:24])=[N:21][CH:22]=3)[C:13]2=[N:12][N:11]=1)(C)(C)C.[ClH:38]>O1CCOCC1>[ClH:38].[F:36][C:29]1[CH:30]=[C:31]([F:35])[C:32]([F:34])=[CH:33][C:28]=1[CH2:27][C@@H:8]([NH2:7])[CH2:9][C:10]1[N:14]2[CH2:15][CH2:16][C:17]3[C:18](=[N:19][C:20]([C:23]([F:24])([F:26])[F:25])=[N:21][CH:22]=3)[C:13]2=[N:12][N:11]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 90695481HCID 90695481、化合物

生成物 1

HCID 87483712HCID 87483712、化合物

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

To 47 mg (0.89 mmol) of tert-butyl{(1R)-1-(2,4,5-trifluorobenzyl)-2-[9-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4′,3′:1,2]pyrido[3,4-d]pyrimidin-3-yl]ethyl}carbamate was added 1.8 mL of 4M HCl in anhydrous dioxane. The mixture was stirred at room temperature for 30 minutes and then concentrated. The residue was washed with diethyl ether and dried to give the title compound as a white solid. LC-MS 429 (M+1).

後処理

  1. concentrationconcentrated
  2. washThe residue was washed with diethyl ether
  3. customdried

出典と根拠

ORDレコード
ord-e1d287dcad2146fb94e045a132434b34
出典データセット
uspto-grants-2009_12
特許番号
US07625888B2

反応ノート

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