4-Chloro-2-trifluoromethylpyrazolo[1.5-a]pyrazine → HCID 131727793、化合物

HRID 1863968ノート

反応式

HRID 1863968 の反応式
[C:1]([O:5][C:6](=[O:24])[NH:7][C@H:8]([CH2:14][C:15]1[CH:20]=[C:19]([F:21])[C:18]([F:22])=[CH:17][C:16]=1[F:23])[CH2:9][C:10]([NH:12][NH2:13])=O)([CH3:4])([CH3:3])[CH3:2].Cl[C:26]1[C:27]2[N:28]([N:32]=[C:33]([C:35]([F:38])([F:37])[F:36])[CH:34]=2)[CH:29]=[CH:30][N:31]=1>>[C:1]([O:5][C:6](=[O:24])[NH:7][C@H:8]([CH2:14][C:15]1[CH:20]=[C:19]([F:21])[C:18]([F:22])=[CH:17][C:16]=1[F:23])[CH2:9][C:10]1[N:31]2[C:26]([C:27]3[N:28]([N:32]=[C:33]([C:35]([F:38])([F:36])[F:37])[CH:34]=3)[CH:29]=[CH:30]2)=[N:13][N:12]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 579737724-Chloro-2-trifluoromethylpyrazolo[1.5-a]pyrazine2 回HCID 57973796HCID 57973796、化合物2 回

生成物 1

HCID 131727793HCID 131727793、化合物

実験手順

A mixture of 7.7 mg (0.22 mmol) of tert-butyl[(1R)-3-hydrazino-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamate (Intermediate 4), 4.9 mg (0.22 mmol) of 4-chloro-2-(trifluoromethyl)pyrazolo[1,5-a]pyrazine (Intermediate 39), and 0.5 mL of xylenes was stirred at reflux for 19 h. The cooled solution was concentrated to yield the title compound, sufficiently pure for use in the next step. LC-MS 515 (M+1).

後処理

  1. temperatureat reflux for 19 h
  2. concentrationThe cooled solution was concentrated

出典と根拠

ORDレコード
ord-d5798a9a36ef485a85a8301247a78eaf
出典データセット
uspto-grants-2009_12
特許番号
US07625888B2

反応ノート

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