Hydrochloric Acid → HCID 25001867、化合物

HRID 1864036ノート

反応式

HRID 1864036 の反応式
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=2[C:11]([NH2:13])=[O:12])[C:5]([Cl:18])=[CH:4][N:3]=1.[N:19]1([CH2:24][C:25]2[CH:26]=[C:27]([CH:29]=[CH:30][CH:31]=2)[NH2:28])[CH2:23][CH2:22][CH2:21][CH2:20]1.Cl>Cl.C(O)(C)C>[Cl:18][C:5]1[C:6]([NH:8][C:9]2[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=2[C:11]([NH2:13])=[O:12])=[N:7][C:2]([NH:28][C:27]2[CH:29]=[CH:30][CH:31]=[C:25]([CH2:24][N:19]3[CH2:20][CH2:21][CH2:22][CH2:23]3)[CH:26]=2)=[N:3][CH:4]=1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 10964073-(Pyrrolidin-1-ylmethyl)anilineHCID 579741762-[(2,5-Dichloropyrimidin-4-yl)amino]benzamide

生成物 1

HCID 25001867HCID 25001867、化合物収率 70.1%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid触媒HCID 3776Isopropanol溶媒

反応条件

温度
95 °C

実験手順

2-[(2,5-Dichloro-4-pyrimidinyl)amino]benzamide (200 mg, 0.6 mmol) and 3-(1-pyrrolidinylmethyl)aniline (134mg, 0.75 mmol) were combined in a vessel with 5 mL isopropanol and 2 drops of 12N HCl. The vessel was sealed and heated with stirring at 95° C. for 18 h. The reaction was cooled to room temperature and the solid was filtered off and washed with isopropanol to give 178 mg (65% yield) of an orange solid as the HCl salt. MS: M(C22H23ClN6O)=422.92, (M+H)+=423 and 425.

後処理

  1. customThe vessel was sealed
  2. temperatureheated
  3. temperatureThe reaction was cooled to room temperature
  4. filtrationthe solid was filtered off
  5. washwashed with isopropanol

出典と根拠

ORDレコード
ord-e44f2a2b90464bf1ab258b3ff7bb9865
出典データセット
uspto-grants-2009_12
特許番号
US07625903B2

反応ノート

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