Chloroacetic Acid → 5-Methoxyuracil

HRID 1864049ノート

反応式

HRID 1864049 の反応式
[CH3:1][O:2][C:3]1[C:4](=[O:10])[NH:5][C:6](=S)[NH:7][CH:8]=1.ClCC(O)=[O:14].Cl>O>[CH3:1][O:2][C:3]1[C:4](=[O:10])[NH:5][C:6](=[O:14])[NH:7][CH:8]=1

参加物

5

反応物 3

HCID 300Chloroacetic AcidHCID 313Hydrochloric AcidHCID 27637595-methoxy-2-sulfanyl-4-pyrimidinol

生成物 1

HCID 811005-Methoxyuracil収率 94%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 5-(methoxy)-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone (21.5 g; 0.137 moles), chloroacetic acid (21.5 g; 0.227 moles), and water (585 mL) was refluxed for 2 h. Concentrated HCl (85 mL) was added and the mixture was then refluxed for 16 h. Upon cooling, a solid formed and was collected by filtration, washed with water and dried to yield the desired product (18.2 g; 94% yield). MS: (M+H)+=143.

後処理

  1. temperaturewas refluxed for 2 h
  2. temperaturethe mixture was then refluxed for 16 h
  3. temperatureUpon cooling
  4. customa solid formed
  5. filtrationwas collected by filtration
  6. washwashed with water
  7. customdried

出典と根拠

ORDレコード
ord-3f6c6f12a8b34b6e8abec49dc8090da2
出典データセット
uspto-grants-2009_12
特許番号
US07625903B2

反応ノート

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