Picolyl chloride hydrochloride → HCID 57974300、化合物
反応式
Cl.[N:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8]Cl.[Cl:10][C:11]1[CH:12]=[C:13]([NH:18][C:19]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][C:27]=3[O:29][CH2:30][C@@H:31]([N:33]([CH3:39])[C:34](=[O:38])[CH2:35][O:36][CH3:37])[CH3:32])[N:22]=[CH:21][N:20]=2)[CH:14]=[CH:15][C:16]=1[OH:17]>>[Cl:10][C:11]1[CH:12]=[C:13]([NH:18][C:19]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][C:27]=3[O:29][CH2:30][C@@H:31]([N:33]([CH3:39])[C:34](=[O:38])[CH2:35][O:36][CH3:37])[CH3:32])[N:22]=[CH:21][N:20]=2)[CH:14]=[CH:15][C:16]=1[O:17][CH2:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][N:2]=1参加物
3
実験手順
The procedure described in Example 3 was repeated using picolyl chloride hydrochloride and N-[(1S)-2-({4-[(3-chloro-4-hydroxyphenyl)amino]quinazolin-5-yl}oxy)-1-methylethyl]-2-methoxy-N-methylacetamide to give the title compound in 39% yield; NMR spectrum (DMSO-d6, 373K) 1.20 (m, 3H), 2.80 (s, 3H), 3.10 (s, 3H), 3.90 (m, 2H), 4.20 (m, 1H), 4.50 (m, 1H), 5.10 (m, 1H), 5.30 (s, 2H), 7.20 (m, 2H), 7.40 (m, 2H), 7.50 (d, 1H), 7.60 (d, 1H), 7.70 (t, 1H), 7.90 (t, 1H), 7.95 (s, 1H), 8.40 (s, 1H), 8.60 (d, 1H), 9.60 (s, 1H); Mass spectrum F 522.2.
出典と根拠
- ORDレコード
- ord-5178cc72e3c24723bd3ae23a55c4fadd
- 出典データセット
- uspto-grants-2009_12