tert-butyl (2R,3S)-3-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate → 2-Pyrrolidinemethanol, 3-hydroxy-, hydrochloride, (2R,3S)-

HRID 1864509ノート

反応式

HRID 1864509 の反応式
[OH:1][C@H:2]1[CH2:6][CH2:5][N:4](C(OC(C)(C)C)=O)[C@@H:3]1[CH2:14][OH:15].[ClH:16].C[C@H]1CCN[C@@H]1CO>>[ClH:16].[OH:15][CH2:14][C@@H:3]1[C@@H:2]([OH:1])[CH2:6][CH2:5][NH:4]1

参加物

3

反応物 2

HCID 10910976tert-butyl (2R,3S)-3-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylateHCID 57463460HCID 57463460、化合物

生成物 1

HCID 156073442-Pyrrolidinemethanol, 3-hydroxy-, hydrochloride, (2R,3S)-

実験手順

The title compound was prepared from 1,1-dimethylethyl (2R, 3S)-3-hydroxy-2-(hydroxymethyl)-1-pyrrolidinecarboxylate using the methods used to prepare [(2S,3S)-3-methyl-2-pyrrolidinyl]methanol hydrochloride. 1H NMR (400 MHz, DMSO-D6) δ ppm 1.8 (m, 1H), 2.0 (m, 1H), 2.5 (m, 2H), 3.2 (m, 2H), 3.3 (m, 1H), 3.5 (m, 1H), 3.6 (m, 1H), 4.1 (m, 1H), 8.7 (s, 1H), 9.5 (m, 1H). ES+=117.97.

出典と根拠

ORDレコード
ord-6b703e435b54497e97a421a205593baa
出典データセット
uspto-grants-2009_12
特許番号
US07625909B2

反応ノート

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