Water → 3-(Methylthio)-4-nitrophenol

HRID 1864666ノート

反応式

HRID 1864666 の反応式
F[C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[CH3:12][S-:13].[Na+].C(=O)([O-])[O-].[K+].[K+].O>CN(C=O)C>[CH3:12][S:13][C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9]

参加物

6

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 5209483-Fluoro-4-nitrophenolHCID 4378561Sodium methanethiolate

生成物 1

HCID 441857023-(Methylthio)-4-nitrophenol収率 90.1%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 3-fluoro-4-nitrophenol (2 g, 12.7 mmol) in dry DMF (67 mL) was added, by aliquots, 2 equivalents of sodium thiomethoxide (1.78 g, 25.5 mmol) followed by 3 equivalents of potassium carbonate (5.27 g, 38.2 mmol). The mixture was stirred at room temperature for 23 hours and then water (100 mL) was added. The mixture was extracted with EtOAc, and the combined organic layers washed successively with water (60 mL) and brine (60 mL) and then dried over MgSO4. The solvent was evaporated under vacuum to provide the title compound (2.12 g, 90%) as a yellow powder. 1H-NMR (δ, ppm, DMSO-d6): 2.44 (s, 3H, HMe), 6.72 (d, 1H, Harom 6, J6-5=9.0 Hz), 6.79 (s, 1H, Harom 2), 8.19 (d, 1H, Harom 5, J5-8=9.1 Hz), 11.20 (broad s, 1H, OH).

後処理

  1. extractionThe mixture was extracted with EtOAc
  2. washthe combined organic layers washed successively with water (60 mL) and brine (60 mL)
  3. dry with materialdried over MgSO4
  4. customThe solvent was evaporated under vacuum

出典と根拠

ORDレコード
ord-b5a76c8177b54b0ca67cddc23d3b0a89
出典データセット
uspto-grants-2009_12
特許番号
US07625922B2

反応ノート

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