Allyl bromide → Methyl 2-(allyloxy)-4-methoxybenzoate

関与物質

役割	名称	HCID	仕込み量
反応物	Allyl bromide	HCID 7841	—
反応物	Cesium carbonate	HCID 10796	—
反応物	Methyl 4-methoxysalicylate	HCID 79523	—
溶媒	Dimethylformamide	HCID 6228	—
溶媒	Ethyl Acetate	HCID 8857	—
生成物	Methyl 2-(allyloxy)-4-methoxybenzoate	HCID 10242646	—

反応手順

To a solution of methyl 4-methoxysalicylate (2.0 g, 11 mmol) in DMF (20 mL) at room temperature was added Cs2CO3 (1.3 eq, 4.7 g) and allyl bromide (1.3 eq, 1.23 mL). After 2 hr, reaction mixture was diluted with EtOAc and washed with water (3×), brine (1×). The organic layer was dried over Na2SO4 and concentrated to provide the product as a pale yellow oil. Product was used without further purification.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07625933B2
出典データセット	uspto-grants-2009_12
ORD ID	ord-d59ac7b80e7844719da3b652a4e54201
出典メモ	uspto-grants-2009_12