Water → 5-Methyl-5-[({4'-[(trifluoromethyl)oxy]-1,1'-biphenyl-4-yl}sulfinyl)methyl]imidazolidine-2,4-dione

HRID 1864746ノート

反応式

HRID 1864746 の反応式
[CH3:1][C:2]1([CH2:9][S:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][C:20]([O:23][C:24]([F:27])([F:26])[F:25])=[CH:19][CH:18]=3)=[CH:13][CH:12]=2)[NH:6][C:5](=[O:7])[NH:4][C:3]1=[O:8].[OH:28]OS([O-])=O.[K+].C(=O)(O)[O-].[Na+].O>CO>[CH3:1][C:2]1([CH2:9][S:10]([C:11]2[CH:12]=[CH:13][C:14]([C:17]3[CH:22]=[CH:21][C:20]([O:23][C:24]([F:25])([F:27])[F:26])=[CH:19][CH:18]=3)=[CH:15][CH:16]=2)=[O:28])[NH:6][C:5](=[O:7])[NH:4][C:3]1=[O:8]

参加物

6

反応物 4

HCID 962WaterHCID 516892Sodium BicarbonateHCID 231334745-Methyl-5-[({4'-[(trifluoromethyl)oxy]-1,1'-biphenyl-4-yl}thio)methyl]imidazolidine-2,4-dioneHCID 23707502Potassium hydroxy sulfite

生成物 1

HCID 231334965-Methyl-5-[({4'-[(trifluoromethyl)oxy]-1,1'-biphenyl-4-yl}sulfinyl)methyl]imidazolidine-2,4-dione収率 43.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

5-methyl-5-[({4′-[(trifluoromethyl)oxy]-1,1′-biphenyl-4-yl}thio)methyl]imidazolidine-2,4-dione (48 mg, 0.112 mmol) was stirred at room temperature with oxone (50 mg), sodium bicarbonate (50 mg), water (5 ml) and Methanol (10 ml) for 18 hours. The solid was filtered off and crystallized from ethanol to give 20 mg of the title compound.

後処理

  1. filtrationThe solid was filtered off
  2. customcrystallized from ethanol

出典と根拠

ORDレコード
ord-2e690ce254a042d3befc334a0c0eac05
出典データセット
uspto-grants-2009_12
特許番号
US07625934B2

反応ノート

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