4-Bromobenzo[b]thiophene → HCID 69023198、化合物

HRID 1865089ノート

反応式

HRID 1865089 の反応式
[CH2:1]([O:3][C:4]([C:6]1[N:7]([CH3:29])[C:8](CC)=[C:9]([C:25]#[N:26])[C:10]=1[C:11]1[CH:16]=[CH:15][C:14](OS(C(F)(F)F)(=O)=O)=[CH:13][CH:12]=1)=[O:5])[CH3:2].Br[C:31]1[C:39]2[CH:38]=[CH:37][S:36][C:35]=2[CH:34]=[CH:33][CH:32]=1>>[CH2:1]([O:3][C:4]([C:6]1[N:7]([CH3:29])[CH:8]=[C:9]([C:25]#[N:26])[C:10]=1[C:11]1[CH:16]=[CH:15][C:14]([C:31]2[C:39]3[CH:38]=[CH:37][S:36][C:35]=3[CH:34]=[CH:33][CH:32]=2)=[CH:13][CH:12]=1)=[O:5])[CH3:2]

参加物

3

反応物 2

HCID 120942084-Bromobenzo[b]thiopheneHCID 57974728HCID 57974728、化合物

生成物 1

HCID 69023198HCID 69023198、化合物

実験手順

Prepare the title compound in the manner analogous to the procedure set fourth in example E-222 using 4-cyano-5-ethyl-1-methyl-3-(4-trifluoromethanesulfonyloxyphenyl)—1H-pyrrole-2-carboxylic acid ethyl ester (prepared in example E-97a or 97b) and 4-bromo-benzo(b)thiophene. Purify the material by silica gel chromatography (Chromatotron™) eluting with methylene chloride to provide the title compound a white solid. Mass spectrum (m/e): 415.2 (M*+1).

後処理

  1. customPurify the material by silica gel chromatography (Chromatotron™)
  2. washeluting with methylene chloride

出典と根拠

ORDレコード
ord-0813bf8b4a404acb8941d749da85b786
出典データセット
uspto-grants-2009_12
特許番号
US07625932B2

反応ノート

読み込み中…