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Sulfanilamide → 4-[2-(2-Fluoro-phenyl)-5-methyl-pyrrol-1-yl]-benzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sulfanilamide | HCID 5333 | — |
| 反応物 | Methyl vinyl ketone | HCID 6570 | — |
| 反応物 | o-Fluorobenzaldehyde | HCID 67970 | — |
| 生成物 | 4-[2-(2-Fluoro-phenyl)-5-methyl-pyrrol-1-yl]-benzenesulfonamide | HCID 68484455 | — |
反応手順
2-Fluorobenzaldehyde and but-3-en-2-one were treated according to the procedure outlined in General Procedure C followed by subjecting the resulting product to conditions outlined in General Procedure D along with p-aminosulfonyl phenylamine to obtain the titled compound. 1H NMR (CDCl3) δ ppm 2.18 (3H), 4.71 (2H), 6.13 (1H), 6.34 (1H), 7.05-7.90 (8H); MS (ESI) m/z 331 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07741364B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-babaad3c2e6448d8a81dcfd8f4619454 |
| 出典メモ | uspto-grants-2010_06 |