Acetic Acid → HCID 69020176、化合物

HRID 1865127

反応式

HRID 1865127 の反応式
[CH3:1][S:2][C:3]1[CH:7]=[CH:6][S:5][C:4]=1[C:8]1[CH:15]=[CH:14][C:11]([CH:12]=O)=[CH:10][CH:9]=1.[C:16]1([CH3:28])[CH:21]=[CH:20][C:19]([S:22]([CH2:25][C:26]#[N:27])(=[O:24])=[O:23])=[CH:18][CH:17]=1.N1CCCCC1.C(O)(=O)C>C1(C)C=CC=CC=1>[CH3:28][C:16]1[CH:17]=[CH:18][C:19]([S:22]([C:25](=[CH:12][C:11]2[CH:14]=[CH:15][C:8]([C:4]3[S:5][CH:6]=[CH:7][C:3]=3[S:2][CH3:1])=[CH:9][CH:10]=2)[C:26]#[N:27])(=[O:24])=[O:23])=[CH:20][CH:21]=1

参加物

6

反応物 4

HCID 176Acetic AcidHCID 8082PiperidineHCID 79776TosylacetonitrileHCID 57975359HCID 57975359、化合物

生成物 1

HCID 69020176HCID 69020176、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a stirring solution of 4-(3-methylthio-2-thienyl)benzaldehyde (1.0 mmol, prepared directly above) and p-toluenesulphonylacetonitrile (1.0 mmol) in toluene, add piperidine (0.05 mmol) and acetic acid (0.3 mmol). Heat the reaction mixture to reflux for 2 hours while using a Dean-Stark trap, remove the heat and concentrate the reaction in vacuo. The crude material can be carried on to the next step without further purification.

後処理

  1. temperatureHeat the reaction mixture
  2. temperatureto reflux for 2 hours
  3. customremove the
  4. temperatureheat
  5. concentrationconcentrate
  6. customthe reaction in vacuo
  7. customThe crude material can be carried on to the next step without further purification

出典と根拠

ORDレコード
ord-e678d31c3812410c82607739188924b7
出典データセット
uspto-grants-2009_12
特許番号
US07625932B2

関連ノート

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