1,4-Dioxane hydrochloride → HCID 69018892、化合物
反応式
C([O:3][C:4](=O)[CH2:5][C:6]1[C:11]([NH2:12])=[CH:10][CH:9]=[C:8]([O:13][CH:14]2[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][O:22][CH3:23])[CH2:16][CH2:15]2)[N:7]=1)C.[ClH:25].O1CCOCC1>C(O)C>[ClH:25].[CH3:23][O:22][CH2:21][CH2:20][N:17]1[CH2:18][CH2:19][CH:14]([O:13][C:8]2[N:7]=[C:6]3[CH2:5][C:4](=[O:3])[NH:12][C:11]3=[CH:10][CH:9]=2)[CH2:15][CH2:16]1参加物
4
実験手順
To a mixture of 5 (0.483 mmol) in ethanol (5 mL) was added 4M HCl/Dioxane (15 mL). The solution was agitated at room temperature for 18 hours. All components in reaction are extremely polar and elute with solvent front. By LCMS, 6 was the major observed ion. The crude material was concentrated and taken directly on to the next step without purification.
後処理
- customAll components in reaction
- washelute with solvent front