Cyclopentanemethanol → 6-(4-Chloro-phenyl)-5-cyclopentylmethoxy-pyrazine-2-carboxylic acid ((1R,2R)-2-hydroxy-cyclohexyl)-amide

反応式

[OH:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[NH:8][C:9]([C:11]1[CH:16]=[N:15][C:14](Br)=[C:13]([C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=2)[N:12]=1)=[O:10].[CH:25]1([CH2:30][OH:31])[CH2:29][CH2:28][CH2:27][CH2:26]1>>[OH:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[NH:8][C:9]([C:11]1[CH:16]=[N:15][C:14]([O:31][CH2:30][CH:25]2[CH2:29][CH2:28][CH2:27][CH2:26]2)=[C:13]([C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=2)[N:12]=1)=[O:10]

参加物

反応物 2

HCID 77195Cyclopentanemethanol

HCID 866169725-bromo-6-(4-chloro-phenyl)-pyrazine-2-carboxylic acid ((1R,2R)-2-hydroxy-cyclohexyl)-amide

生成物 1

HCID 866169716-(4-Chloro-phenyl)-5-cyclopentylmethoxy-pyrazine-2-carboxylic acid ((1R,2R)-2-hydroxy-cyclohexyl)-amide

実験手順

The title compound was prepared in analogy to example 26 starting from 5-bromo-6-(4-chloro-phenyl)-pyrazine-2-carboxylic acid ((1R,2R)-2-hydroxy-cyclohexyl)-amide and replacing ethylenglycolmonomethylether by cyclopentylmethanol. MS (ISP) (M+H+)=430.1.

出典と根拠

ORDレコード: ord-6b087d823dff4ed0b7eaa456b585c71f
出典データセット: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07629346B2

反応ノート

読み込み中…