Water → 5-amino-1-(2-phenylethyl)-1H-pyrazole-4-carboxylic acid

反応式

[OH:1]S(O)(=O)=O.[NH2:6][C:7]1[N:11]([CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:10]=[CH:9][C:8]=1[C:20]#N.[OH2:22]>>[NH2:6][C:7]1[N:11]([CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:10]=[CH:9][C:8]=1[C:20]([OH:1])=[O:22]

参加物

反応物 3

HCID 962Water2 回

HCID 1118Sulfuric Acid

HCID 106085935-Amino-1-phenethyl-1H-pyrazole-4-carbonitrile

生成物 1

HCID 220154975-amino-1-(2-phenylethyl)-1H-pyrazole-4-carboxylic acid収率 47%

反応条件

温度: 60 °C

実験手順

A mixture of conc. H2SO4 (15 mL) and water (15 mL) was treated with 5-amino-1-(2-phenylethyl)-1H-pyrazole-4-carbonitrile (5.0 g, 23.6 mmol), heated at 60° C. for 1 h, poured into water, extracted with EtOAc, dried (MgSO4), concentrated in vacuo, and recrystallised (EtOAc/MeOH) to give the title compound (2.53 g, 47%) as a cream solid.