2-Fluoro-5-methylpyridine → 1-(2-Fluoro-5-methylpyridin-3-yl)methanamine

反応式

[CH2:1]([C:3]1[CH:4]=[C:5]([CH2:10][NH2:11])[C:6]([F:9])=[N:7][CH:8]=1)C.Cl.FC1C=CC(C)=CN=1>>[F:9][C:6]1[C:5]([CH2:10][NH2:11])=[CH:4][C:3]([CH3:1])=[CH:8][N:7]=1

参加物

反応物 2

HCID 27746352-Fluoro-5-methylpyridine

HCID 66732973HCID 66732973、化合物

生成物 1

HCID 534269501-(2-Fluoro-5-methylpyridin-3-yl)methanamine

実験手順

(2-fluoro-5-methylpyridin-3-yl)methanamine (2-e) was prepared by the same synthetic route as that of (2-g) but utilizing the commercially available 2-fluoro-5-methylpyridine (2-c) as a starting material; 1H NMR (500 MHz, DMSO-d6) δ 8.65 (bs, 3H), 8.07 (d, 1H, J=1.0 Hz), 8.01 (dd, 1H, J=15.5, 3.0 Hz), 4.02 (s, 2H), 2.30 (s, 3H).

出典と根拠

ORDレコード: ord-d0b3b5593b5f426abe90c03a40159deb
出典データセット: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07629367B2

反応ノート

読み込み中…

参加物