Hydrochloric Acid → 2-Cyclopropyl-6-fluorophenol
反応式
C(=O)([O-])[O-].[K+].[K+].C([O:10][C:11]1[C:16]([F:17])=[CH:15][CH:14]=[CH:13][C:12]=1[CH:18]1[CH2:20][CH2:19]1)(=O)C.Cl>CO>[CH:18]1([C:12]2[CH:13]=[CH:14][CH:15]=[C:16]([F:17])[C:11]=2[OH:10])[CH2:20][CH2:19]1参加物
5
実験手順
Potassium carbonate (911 mg, 6.60 mmol) was added to a solution of 2-cyclopropyl-6-fluorophenyl acetate (640 mg, 3.30 mmol) in methanol (4 ml), and the mixture was stirred at room temperature for 1 hour. After 1M hydrochloric acid was added to the reaction mixture to adjust pH to 2, this was extracted with acetic acid. The organic layer was combined and washed with a saturated aqueous NaCl solution, followed by drying with anhydrous sodium sulfate. After the solid was removed by filtration, the filtrate was concentrated to obtain 497 mg of 2-cyclopropyl-6-fluorophenol.
後処理
- extractionthis was extracted with acetic acid
- washwashed with a saturated aqueous NaCl solution
- dry with materialby drying with anhydrous sodium sulfate
- customAfter the solid was removed by filtration
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-d3ae4b87efa84faf837aef6bb5053085
- 出典データセット
- uspto-grants-2009_12
- 特許番号
- US07629494B2
反応ノート
読み込み中…