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Bromine → 3-bromo-4-(2,4-difluorobenzyloxy)-1H-pyridin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | 4-(2,4-difluorobenzyloxy)-1H-pyridin-2-one | HCID 22050390 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 3-bromo-4-(2,4-difluorobenzyloxy)-1H-pyridin-2-one | HCID 22050832 | 102.1% |
反応手順
To an ice-cold solution of 4-(2,4-difluorobenzyloxy)-1H-pyridin-2-one (0.75 g, 3.1 mmol) in AcOH (12 mL) was added a solution of bromine (0.2 mL, 3.5 mmol) in AcOH (6 mL), and the reaction mixture was stirred 10 min. The solvent was removed under reduced pressure to afford 3-bromo-4-(2,4-difluorobenzyloxy)-1H-pyridin-2-one as a white solid (1.0 g, 100%): ESI MS m/z 299 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07629363B2 |
| 出典データセット | uspto-grants-2009_12 |
| ORD ID | ord-6152d301c3d547dda88e0ab9fbfb0c8d |
| 出典メモ | uspto-grants-2009_12 |