Water → HCID 57979569、化合物

HRID 1867614ノート

反応式

HRID 1867614 の反応式
[C:1]1([N:7]2[CH:11]=[C:10]([C:12]3[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=3)[C:9](=[O:18])[NH:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O>C(O)(=O)C.Cl.[Pt]=O>[C:1]1([N:7]2[CH:11]=[C:10]([CH:12]3[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]3)[C:9](=[O:18])[NH:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

6

反応物 2

HCID 962WaterHCID 685657321-Phenyl-4-pyridin-4-yl-1,2-dihydro-3H-pyrazol-3-one

生成物 1

HCID 57979569HCID 57979569、化合物

試薬・触媒・溶媒 3

HCID 82844Platinum oxide (PtO)触媒HCID 176Acetic Acid溶媒HCID 313Hydrochloric Acid溶媒

実験手順

Platinum oxide (60 mg) was added to a solution of 1-phenyl-4-pyridin-4-yl-1,2-dihydro-3H-pyrazol-3-one (180 mg, 0.758 mmol) in acetic acid (12 mL), concentrated hydrochloric acid (0.100 mL), and water (5 mL). The reaction vessel was evacuated and back-filled with nitrogen (3×), then back-filled with hydrogen (50 psi). After 5 h the mixture was filtered and concentrated to give the title compound. MS 244.3 (M+1).

後処理

  1. customThe reaction vessel was evacuated
  2. additionback-filled with nitrogen (3×)
  3. additionback-filled with hydrogen (50 psi)
  4. filtrationAfter 5 h the mixture was filtered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-527ef4f21ce043febf36a3b1e30f01ab
出典データセット
uspto-grants-2009_12
特許番号
US07632832B2

反応ノート

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