Methanesulfonyl chloride → N-(4-bromo-2-fluorophenyl)methanesulfonamide
反応式
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([F:9])[CH:3]=1.[CH3:10][S:11](Cl)(=[O:13])=[O:12]>ClCCl.N1C=CC=CC=1>[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][S:11]([CH3:10])(=[O:13])=[O:12])=[C:4]([F:9])[CH:3]=1参加物
4
実験手順
Procedure MM: To a stirring solution of 4-bromo-2-fluoroaniline (1.0 mmol) in 3:1 dichloromethane/pyridine, add methanesulfonyl chloride (1.5 mmol) and stir at room temperature for 18 hours. After this time, wash the reaction with 1N hydrochloric acid while extracting with dichoromethane. Purify the title compound via radial chromatography eluting with ethyl acetate and hexane.
後処理
- washAfter this time, wash
- customthe reaction with 1N hydrochloric acid
- extractionwhile extracting with dichoromethane
- customPurify the title compound via radial chromatography
- washeluting with ethyl acetate and hexane
出典と根拠
- ORDレコード
- ord-92e976a67c5a480188b2bf6350597e2c
- 出典データセット
- uspto-grants-2009_12
- 特許番号
- US07632857B2
反応ノート
読み込み中…