ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

1,2-Ethanediamine, N1,N1-bis(1-methylethyl)- → 4-(2-Diisopropylaminoethylamino)benzenesulfonic acid 2-aminobenzothiazol-6-yl ester

HRID 1867976
ノート
印刷プレビュー

反応式

HRID 1867976 の反応式
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([O:11][S:12]([C:15]3[CH:20]=[CH:19][C:18](F)=[CH:17][CH:16]=3)(=[O:14])=[O:13])[CH:8]=[CH:7][C:5]=2[N:6]=1.[CH:22]([N:25]([CH:29]([CH3:31])[CH3:30])[CH2:26][CH2:27][NH2:28])([CH3:24])[CH3:23]>CN1C(=O)CCC1.C(OCC)(=O)C>[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([O:11][S:12]([C:15]3[CH:20]=[CH:19][C:18]([NH:28][CH2:27][CH2:26][N:25]([CH:29]([CH3:31])[CH3:30])[CH:22]([CH3:24])[CH3:23])=[CH:17][CH:16]=3)(=[O:14])=[O:13])[CH:8]=[CH:7][C:5]=2[N:6]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 2

HCID 84591,2-Ethanediamine, N1,N1-bis(1-methylethyl)-HCID 579808144-Fluorobenzenesulfonic acid 2-aminobenzothiazol-6-yl ester2 回

生成物 1

HCID 579808584-(2-Diisopropylaminoethylamino)benzenesulfonic acid 2-aminobenzothiazol-6-yl ester収率 99.1%

試薬・触媒・溶媒 2

HCID 8857Ethyl Acetate溶媒HCID 13387N-methyl-2-pyrrolidone
溶媒

実験手順

A solution of 4-fluorobenzenesulfonic acid 2-aminobenzothiazol-6-yl ester (intermediate 16) (100 mg, 0.225 mmol) and N,N-diisopropylethylenediamine (395 μl, 2.25 mmol) in 5 ml of NMP is heated at 150° C. by microwave using an “Emrys™ Optimizer” machine for 20 minutes. The crude reaction product is taken up in 50 ml of ethyl acetate and the resulting solution is washed with 5 times 50 ml of water. After separation of the phases by settling, the organic phase is dried over sodium sulfate, filtered and evaporated under reduced pressure to give 100 mg of 4-(2-diisopropylaminoethylamino)benzenesulfonic acid 2-aminobenzothiazol-6-yl ester.

後処理

  1. customfor 20 minutes
  2. customThe crude reaction product
  3. washthe resulting solution is washed with 5 times 50 ml of water
  4. customAfter separation of the phases
  5. dry with materialthe organic phase is dried over sodium sulfate
  6. filtrationfiltered
  7. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-f610471f86664f0d8ae9a74b2c62612b
出典データセット
uspto-grants-2009_12
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07632952B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート