Diethyl Ether → HCID 68508768、化合物
反応式
C([O:5][C:6]([N:8]1[C:12]([CH3:13])=[C:11]([Cl:14])[C:10]([C:15]([F:18])([F:17])[F:16])=[N:9]1)=[O:7])(C)(C)C.Cl.O1CCOCC1.CCOCC>ClCCl>[Cl:14][C:11]1[C:10]([C:15]([F:17])([F:16])[F:18])=[N:9][N:8]([C:6]([OH:7])=[O:5])[C:12]=1[CH3:13]参加物
5
実験手順
To a stirred solution of 43.62 mmol of 4-chloro-5-methyl-3-trifluoromethylpyrazole-1-carboxylic acid tertbutyl ester in 20 mL of dichloromethane, carefully add 40 mL of 4M HCl/dioxane. The reaction mixture was allowed to stir for 2 hours. Add fresh ether and filter the white solid obtained. Vaccum dry to give the title compound 4-chloro-5-methyl-3-trifluoromethylpyrazole-1-carboxylic acid in 96% yield. LC-MS m/z=242 (M+).
後処理
- filtrationfilter the white solid
- customobtained
- customVaccum dry
出典と根拠
- ORDレコード
- ord-d2e446811f3a4cb78802b0057c78c1ac
- 出典データセット
- uspto-grants-2009_12
- 特許番号
- US07635698B2
反応ノート
読み込み中…