化工社化工社 化学情報印刷レポート · 研究参考用
Potassium Carbonate → (2-Methyl-imidazol-1-yl)-acetic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Methylimidazole | HCID 12749 | — |
| 反応物 | Methyl bromoacetate | HCID 60984 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | (2-Methyl-imidazol-1-yl)-acetic acid methyl ester | HCID 28940036 | 47% |
反応手順
4 ml of bromo acetic acid methyl ester is dissolved in 30 ml DMF and 5.2 g of 2-methylimidazole and 11.2 g potassium carbonate are added. The reaction mixture is stirred at room temperature for several hours and then subjected to aqueous work up. After removal of the solvent the pure product is obtained by flash chromatography in 47 to 78% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07741488B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-0bedc00b6d0b4bcbacdd64180013cb6f |
| 出典メモ | uspto-grants-2010_06 |