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4-[(4-{3-[(S)-5-Benzyloxycarbonylamino-1-(carbamoyl)pentylamino]propoxy}-2-methylphenyl)methyl]-3-(beta-D-glucopyranosyloxy)-5-isopropyl-1H-pyrazole → 4-[(4-(3-[(S)-5-Amino-1-(carbamoyl)pentylamino]propoxy)-2-methylphenyl)methyl]-3-(beta-D-glucopyranosyloxy)-5-isopropyl-1H-pyrazole

HRID 1869005
ノート
印刷プレビュー

反応式

HRID 1869005 の反応式
C(OC([NH:11][CH2:12][CH2:13][CH2:14][CH2:15][C@H:16]([NH:20][CH2:21][CH2:22][CH2:23][O:24][C:25]1[CH:30]=[CH:29][C:28]([CH2:31][C:32]2[C:33]([O:40][C@@H:41]3[O:49][C@H:48]([CH2:50][OH:51])[C@@H:46]([OH:47])[C@H:44]([OH:45])[C@H:42]3[OH:43])=[N:34][NH:35][C:36]=2[CH:37]([CH3:39])[CH3:38])=[C:27]([CH3:52])[CH:26]=1)[C:17](=[O:19])[NH2:18])=O)C1C=CC=CC=1>CO.[C].[Pd]>[NH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C@H:16]([NH:20][CH2:21][CH2:22][CH2:23][O:24][C:25]1[CH:30]=[CH:29][C:28]([CH2:31][C:32]2[C:33]([O:40][C@@H:41]3[O:49][C@H:48]([CH2:50][OH:51])[C@@H:46]([OH:47])[C@H:44]([OH:45])[C@H:42]3[OH:43])=[N:34][NH:35][C:36]=2[CH:37]([CH3:39])[CH3:38])=[C:27]([CH3:52])[CH:26]=1)[C:17](=[O:19])[NH2:18]
参加物実験手順後処理出典と根拠反応ノート

参加物

4

反応物 1

HCID 689410364-[(4-{3-[(S)-5-Benzyloxycarbonylamino-1-(carbamoyl)pentylamino]propoxy}-2-methylphenyl)methyl]-3-(beta-D-glucopyranosyloxy)-5-isopropyl-1H-pyrazole

生成物 1

HCID 104160554-[(4-(3-[(S)-5-Amino-1-(carbamoyl)pentylamino]propoxy)-2-methylphenyl)methyl]-3-(beta-D-glucopyranosyloxy)-5-isopropyl-1H-pyrazole収率 93.7%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887
Methanol
溶媒

実験手順

To a solution of 4-[(4-{3-[(S)-5-benzyloxycarbonylamino-1-(carbamoyl)pentylamino]propoxy}-2-methylphenyl)-methyl]-3-(β-D-glucopyranosyloxy)-5-isopropyl-1H-pyrazole (0.17 g) in methanol (4 mL) was added 10% palladium-carbon powder (30 mg), and the mixture was stirred at room temperature under a hydrogen atmosphere for 1 hour. The insoluble material was removed by filtration, and the filtrate was concentrated under reduced pressure to give the title compound (0.13 g).

後処理

  1. customThe insoluble material was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-e8d858f372a243b1b35b9cef75f47297
出典データセット
uspto-grants-2009_12
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07635684B2

反応ノート

読み込み中…

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