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3-Ethynylaniline hydrochloride → (6-Carbomethoxyquinazolin-4-yl)-(3-ethynylphenyl)-amine Hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Ethynylaniline hydrochloride | HCID 18925023 | — |
| 反応物 | Methyl 4-chloroquinazoline-6-carboxylate | HCID 18925080 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 溶媒 | tert-Butanol | HCID 6386 | — |
| 生成物 | (6-Carbomethoxyquinazolin-4-yl)-(3-ethynylphenyl)-amine Hydrochloride | HCID 18925071 | — |
反応手順
4-Chloro-6-carbomethoxyquinazoline (100 mg, 0.450 mmol) and 3-ethynylaniline hydrochloride (53.4 mg, 0.456 mmol) were refluxed in 2 mL of tert-butyl alcohol for 2 hours, cooled, diluted with 2 mL of isopropyl alcohol and filtered to afford solid title product which was washed with 10 mL of diethyl ether and dried, in vacuo, at 70° C., 122 mg (80%); mp 232°-233° C. (dec).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | USRE041065E1 |
| 出典データセット | uspto-grants-2009_12 |
| ORD ID | ord-e3575eab7f0144ebb14c6edee87de436 |
| 出典メモ | uspto-grants-2009_12 |