Triethylamine → 3,3-dichloro-N-{3-[2,6-dichloro-4-(3,3-dichloro-allyloxy)-phenoxy]-propyl}-2-(4-trifluoromethyl-phenyl)-acrylamide

HRID 1869139ノート

反応式

HRID 1869139 の反応式
[Cl:1][C:2]([Cl:17])=[C:3]([C:7]1[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=1)[C:4]([OH:6])=O.O=C1N(P(Cl)(N2CCOC2=O)=O)CCO1.C(N(CC)CC)C.[Cl:40][C:41]1[CH:51]=[C:50]([O:52][CH2:53][CH:54]=[C:55]([Cl:57])[Cl:56])[CH:49]=[C:48]([Cl:58])[C:42]=1[O:43][CH2:44][CH2:45][CH2:46][NH2:47]>ClCCl.C(OCC)(=O)C>[Cl:17][C:2]([Cl:1])=[C:3]([C:7]1[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=1)[C:4]([NH:47][CH2:46][CH2:45][CH2:44][O:43][C:42]1[C:48]([Cl:58])=[CH:49][C:50]([O:52][CH2:53][CH:54]=[C:55]([Cl:57])[Cl:56])=[CH:51][C:41]=1[Cl:40])=[O:6]

参加物

7

反応物 4

HCID 8471TriethylamineHCID 152842Bis(2-oxo-3-oxazolidinyl)phosphinic chlorideHCID 158697443-[2,6-Dichloro-4-(3,3-dichloro-allyloxy)-phenoxy]-propylamineHCID 866130803,3-Dichloro-2-(4-trifluoromethyl-phenyl)-acrylic acid

生成物 1

HCID 112964533,3-dichloro-N-{3-[2,6-dichloro-4-(3,3-dichloro-allyloxy)-phenoxy]-propyl}-2-(4-trifluoromethyl-phenyl)-acrylamide

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8857Ethyl Acetate溶媒

実験手順

74 mg of 3,3-dichloro-2-(4-trifluoromethyl-phenyl)-acrylic acid, 67 mg of bis(2-oxo-3-oxazolidinyl)-phosphinic acid chloride, 53 mg of triethylamine and 100 mg of 3-[2,6-dichloro-4-(3,3-dichloro-allyloxy)-phenoxy]-propylamine are stirred in 2 ml of dichloromethane for 48 hours at 40° C. The reaction mixture is diluted with 16 ml of ethyl acetate and washed twice with aqueous potassium carbonate solution. After concentration of the organic phase and purification over silica gel, the title compound is obtained.

後処理

  1. washwashed twice with aqueous potassium carbonate solution
  2. customAfter concentration of the organic phase and purification over silica gel

出典と根拠

ORDレコード
ord-a20d22ad4fe74cfda6fd3bc395557689
出典データセット
uspto-grants-2009_12
特許番号
US07638514B2

反応ノート

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