1,1-Dimethylethyl 4-[(1-ethyl-4-piperidinyl)methyl]-1-piperidinecarboxylate → 1-Ethyl-4-(piperidin-4-ylmethyl)piperidine

HRID 1869626ノート

反応式

HRID 1869626 の反応式
[CH2:1]([N:3]1[CH2:8][CH2:7][CH:6]([CH2:9][CH:10]2[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]2)[CH2:5][CH2:4]1)[CH3:2]>Cl.O1CCOCC1>[CH2:1]([N:3]1[CH2:4][CH2:5][CH:6]([CH2:9][CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH2:7][CH2:8]1)[CH3:2]

参加物

3

反応物 1

HCID 688869521,1-Dimethylethyl 4-[(1-ethyl-4-piperidinyl)methyl]-1-piperidinecarboxylate

生成物 1

HCID 534072191-Ethyl-4-(piperidin-4-ylmethyl)piperidine収率 87.4%

試薬・触媒・溶媒 1

HCID 204431481,4-Dioxane hydrochloride溶媒

実験手順

1,1-Dimethylethyl 4-[(1-ethyl-4-piperidinyl)methyl]-1-piperidinecarboxylate (may be prepared as described in Description 7) (2.5 g) was stirred in a solution of HCl-Dioxane (70 ml, 4M) for 2 h. The solvent was evaporated and the resultant hydrochloride salt was dissolved in saturated potassium carbonate (25 ml). The solution was extracted into DCM (3×50 ml) and the combined organics dried (MgSO4) and evaporated to give the title compound (D8) (1.48 g).

後処理

  1. customThe solvent was evaporated
  2. dissolutionthe resultant hydrochloride salt was dissolved in saturated potassium carbonate (25 ml)
  3. extractionThe solution was extracted into DCM (3×50 ml)
  4. dry with materialthe combined organics dried (MgSO4)
  5. customevaporated

出典と根拠

ORDレコード
ord-5f11804044cf414b8dd5924d975cae79
出典データセット
uspto-grants-2009_12
特許番号
US07638631B2

反応ノート

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