1,1-Dimethylethyl 4-{[1-(cyclopropylmethyl)-4-piperidinyl]methyl}-1-piperidinecarboxylate → 1-(Cyclopropylmethyl)-4-(4-piperidinylmethyl)piperidine

HRID 1869628ノート

反応式

HRID 1869628 の反応式
[CH:1]1([CH2:4][N:5]2[CH2:10][CH2:9][CH:8]([CH2:11][CH:12]3[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]3)[CH2:7][CH2:6]2)[CH2:3][CH2:2]1>Cl.O1CCOCC1>[CH:1]1([CH2:4][N:5]2[CH2:10][CH2:9][CH:8]([CH2:11][CH:12]3[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]3)[CH2:7][CH2:6]2)[CH2:2][CH2:3]1

参加物

3

反応物 1

HCID 688855731,1-Dimethylethyl 4-{[1-(cyclopropylmethyl)-4-piperidinyl]methyl}-1-piperidinecarboxylate

生成物 1

HCID 688844871-(Cyclopropylmethyl)-4-(4-piperidinylmethyl)piperidine収率 71.2%

試薬・触媒・溶媒 1

HCID 204431481,4-Dioxane hydrochloride溶媒

実験手順

1,1-Dimethylethyl 4-{[1-(cyclopropylmethyl)-4-piperidinyl]methyl}-1-piperidinecarboxylate (may be prepared as described in Description 9) (2.0 g) was stirred in a solution of HCl-Dioxane (700 ml, 4M) for 2 h. The solvent was evaporated and the resultant yellow solid was dissolved in saturated potassium carbonate (25 ml). The solution was extracted into dichloromethane (3×50 ml) and the combined organics dried (MgSO4) and evaporated to give the title compound (D10) (1.0 g).

後処理

  1. customThe solvent was evaporated
  2. dissolutionthe resultant yellow solid was dissolved in saturated potassium carbonate (25 ml)
  3. extractionThe solution was extracted into dichloromethane (3×50 ml)
  4. dry with materialthe combined organics dried (MgSO4)
  5. customevaporated

出典と根拠

ORDレコード
ord-d559086f863143e38ba2ee3ddb87f8ba
出典データセット
uspto-grants-2009_12
特許番号
US07638631B2

反応ノート

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