1,1-Dimethylethyl 4-{[1-(1-methylethyl)-4-piperidinyl]methyl}-1-piperidinecarboxylate → 1-Methyl-4-(4-piperidinylmethyl)piperidine

HRID 1869632ノート

反応式

HRID 1869632 の反応式
C[CH:2]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][CH:11]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]2)[CH2:6][CH2:5]1)C>Cl.O1CCOCC1>[CH3:2][N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[CH2:6][CH2:5]1

参加物

3

反応物 1

HCID 688888451,1-Dimethylethyl 4-{[1-(1-methylethyl)-4-piperidinyl]methyl}-1-piperidinecarboxylate

生成物 1

HCID 534072351-Methyl-4-(4-piperidinylmethyl)piperidine収率 35.1%

試薬・触媒・溶媒 1

HCID 204431481,4-Dioxane hydrochloride溶媒

実験手順

1,1-Dimethylethyl 4-{[1-(1-methylethyl)-4-piperidinyl]methyl}-1-piperidinecarboxylate (may be prepared as described in Description 3) (3.1 g) was stirred in a solution of HCl-Dioxane (50 ml, 4M) for 2 h. The solvent was evaporated and the product was dissolved in saturated potassium carbonate (25 ml). The solution was extracted into dichloromethane (3×50 ml) and the combined organics dried (Na2SO4) and evaporated to give the title compound (D19) (0.658 g).

後処理

  1. customThe solvent was evaporated
  2. dissolutionthe product was dissolved in saturated potassium carbonate (25 ml)
  3. extractionThe solution was extracted into dichloromethane (3×50 ml)
  4. dry with materialthe combined organics dried (Na2SO4)
  5. customevaporated

出典と根拠

ORDレコード
ord-8c6b9b13e72e45838b83f2b63b23aba9
出典データセット
uspto-grants-2009_12
特許番号
US07638631B2

反応ノート

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