Toluene → 3-(4-Diethylamino-2-hydroxy-phenyl)-but-2-enoic acid ethyl ester
反応式
[CH2:1]([O:3][C:4](C=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=[O:5])[CH3:2].[CH2:26]([N:28]([CH2:39][CH3:40])[C:29]1[CH:34]=[CH:33][C:32]([C:35](=O)[CH3:36])=[C:31]([OH:38])[CH:30]=1)[CH3:27].[C:41]1(C)C=CC=CC=1>>[CH2:1]([O:3][C:4](=[O:5])[CH:36]=[C:35]([C:32]1[CH:33]=[CH:34][C:29]([N:28]([CH2:39][CH3:40])[CH2:26][CH3:27])=[CH:30][C:31]=1[OH:38])[CH3:41])[CH3:2]参加物
4
実験手順
To a suspension of 5.27 g ethoxycarbonylmethylene-triphenylphosphorane in 10 ml of toluene, a solution of 2.02 g 1-(4-diethylamino-2-hydroxy-phenyl)-ethanone (DE 28 44 606) was dropped in at room temperature. Then the reaction mixture was heated to reflux. After refluxing for 31 hours the mixture was cooled down and evaporated to dryness. The resulting dark oil was purified by chromatography to yield a colourless oil.