Potassium Hydroxide → O-Coumaric Acid

HRID 1870576

反応式

HRID 1870576 の反応式
C([O:3][C:4](=[O:14])[CH:5]=[CH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[OH:13])C.[OH-].[K+]>C(O)C.O>[OH:13][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=1/[CH:6]=[CH:5]/[C:4]([OH:14])=[O:3]

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 576496Ethyl 3-(2-hydroxyphenyl)prop-2-enoate

生成物 1

HCID 637540O-Coumaric Acid収率 51.9%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

To a solution of 100.0 g 3-(2-hydroxy-phenyl)-acrylic acid ethyl ester in 500 ml of ethanol, a solution of 50.9 g potassium hydroxide in 500 ml of water was dropped in at room temperature. After stirring at reflux for 28 hours, the reaction mixture was concentrated. The residue was diluted with 500 ml HCl 2N and extracted with ether. The organic phase was washed with 2N HCl and water, dried and evaporated to dryness. The resulting solid was recrystallized to yield 44.3 g of colourless crystals.

後処理

  1. temperatureat reflux for 28 hours
  2. concentrationthe reaction mixture was concentrated
  3. additionThe residue was diluted with 500 ml HCl 2N
  4. extractionextracted with ether
  5. washThe organic phase was washed with 2N HCl and water
  6. customdried
  7. customevaporated to dryness
  8. customThe resulting solid was recrystallized

出典と根拠

ORDレコード
ord-d15b5863f9d84dc9ac9ba57a6513e3e7
出典データセット
uspto-grants-2000_08
特許番号
US06096918

関連ノート

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