Ethanol → Ethyl 4-chloro-2-fluorophenylacetate

反応式

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]#N)=[C:4]([F:11])[CH:3]=1.[OH2:12].[CH2:13]([OH:15])[CH3:14]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:15][CH2:13][CH3:14])=[O:12])=[C:4]([F:11])[CH:3]=1

参加物

反応物 3

HCID 702Ethanol

HCID 962Water

HCID 2736569(4-Chloro-2-fluoro-phenyl)-acetonitrile

生成物 1

HCID 4518464Ethyl 4-chloro-2-fluorophenylacetate

実験手順

Then, 15.1 g of 4-chloro-2-fluorophenylacetonitrile was dissolved in 150 ml of ethanol, to which 10 ml of suiliric acid was added, and the mixture was heated under reflux for 65 hours. After completion of the reaction, the reaction mixture was poured into water and extracted with ethyl acetate. The organic layer was washed with saturated sodium chloride solution, dried, and concentrated. The residue was subjected to silica gel column chromatography, which afforded 17.8 g of ethyl 4-chloro-2-fluorophenylacetate.