関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sulfamide | HCID 82267 | — |
| 反応物 | 1,2-Bis(3-fluorophenyl)ethane-1,2-dione | HCID 22574214 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 3,4-bis-(3-Fluorophenyl)-1,2,5-thiadiazole-1,1-dioxide | HCID 68570954 | 72.8% |
反応手順
Hydrogen chloride is bubbled through a solution of 3,3′-difluorobenzil (20) (3.81 g, 15.7 mmol) and sulfamide (1.53 g, 15.9 mmol) in methanol (15 mL) for 0.5 min followed by heating at 66° C. for 2 h. The reaction mixture is cooled to RT, the solvent rotary evaporated, and the residue triturated from heptane to give 3.50 g of the product 21.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07741493B2 |
|---|
| 出典データセット | uspto-grants-2010_06 |
|---|
| ORD ID | ord-534affd4eb524b5fbc80708d57bf766a |
|---|
| 出典メモ | uspto-grants-2010_06 |
|---|
