Water → HCID 136093607、化合物

HRID 1871840ノート

反応式

HRID 1871840 の反応式
[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[C:2]1=[C:11]1[C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=3[O:14][C:13]([C:21]3[CH:26]=[CH:25][C:24]([O:27]C)=[CH:23][CH:22]=3)=[N:12]1)[CH2:8]2.B(I)(I)I.O>C(Cl)Cl>[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[C:2]1=[C:11]1[C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=3[O:14][C:13]([C:21]3[CH:26]=[CH:25][C:24]([OH:27])=[CH:23][CH:22]=3)=[N:12]1)[CH2:8]2

参加物

5

反応物 3

HCID 962Water2 回HCID 83546Borane, triiodo-HCID 18689383HCID 18689383、化合物

生成物 1

HCID 136093607HCID 136093607、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 6 mmol 4-adamantylidene-2-(4'-methoxyphenyl)-4H-1,3-benzoxazine in 20 ml absolute methylene chloride is added dropwise to a solution of 12 mmol boron triiodide while stirring at -25° C. with the exclusion of air and water. The mixture is heated to room temperature within one hour and stirred for a further 4 hours. After admixing with 50 ml water the organic phase is separated and dried over sodium sulfate. The solvent is removed by distillation. The oily residue is separated by column chromatography (silica gel: ethyl acetate/petroleum ether 1:3).

後処理

  1. customis separated
  2. dry with materialdried over sodium sulfate
  3. customThe solvent is removed by distillation
  4. customThe oily residue is separated by column chromatography (silica gel: ethyl acetate/petroleum ether 1:3)

出典と根拠

ORDレコード
ord-5c659b3a32234956bf5e09651599bcd3
出典データセット
uspto-grants-2000_08
特許番号
US06107036

反応ノート

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