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Water → 1-(Bromomethyl)-3-ethylbenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Phosphorus tribromide | HCID 24614 | — |
| 反応物 | (3-Ethylphenyl)methanol | HCID 104659 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | 1-(Bromomethyl)-3-ethylbenzene | HCID 22003656 | — |
反応手順
Phosphorous tribromide (5.3 ml) was added to a solution of the product from step (i) (7.6 g) in benzene (150 ml) at 0° C. After 3 hours, water (40 ml) was added and the mixture warmed to room temperature and extracted with ethyl acetate. The organic phase was dried (MgSO4) and evaporated. Purified by chromatography eluting with 2% ethyl acetate in isohexane. Yield 8.0 g.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06107297 |
| 出典データセット | uspto-grants-2000_08 |
| ORD ID | ord-b501f9e1eb8544469e9e0de14223e35f |
| 出典メモ | uspto-grants-2000_08 |