化工社化工社 化学情報印刷レポート · 研究参考用
1-(Bromomethyl)-3-ethylbenzene → 2-[2-[2-(3-Ethylphenyl)ethyl]-4-methylphenyl]-4,5-dihydro-4,4-dimethyloxazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(Bromomethyl)-3-ethylbenzene | HCID 22003656 | — |
| 反応物 | 2-[2,4-Dimethylphenyl]-4,5-dihydro-4,4-dimethyloxazole | HCID 22117273 | — |
| 反応物 | Butyllithium | HCID 178418339 | — |
| 溶媒 | 2-Methylpentane | HCID 7892 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-[2-[2-(3-Ethylphenyl)ethyl]-4-methylphenyl]-4,5-dihydro-4,4-dimethyloxazole | HCID 18689713 | — |
反応手順
n-Butyllithium (16.8 ml of a 2.5M solution in isohexane) was added dropwise to a stirred solution of the product of step (iii) (8.13 g) in dry tetrahydrofuran (ISOml) at 0° C. under nitrogen. After 1 hour, the product of step (ii) (8.0 g) in tetrahydrofliran (60 ml) was added. After 1 hour, the reaction was quenched with aqueous ammonium chloride and partitioned between ethyl acetate and water. The organic solution was dried (MgSO4) and evaporated. Purification was by chromatography eluting with 5% ethyl acetate in isohexane. Yield 4.93 g.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06107297 |
| 出典データセット | uspto-grants-2000_08 |
| ORD ID | ord-6131338cbdc04d71916f960b0699ee4f |
| 出典メモ | uspto-grants-2000_08 |