Cesium carbonate → HCID 86755658、化合物

HRID 1871994ノート

反応式

HRID 1871994 の反応式
[CH2:1]([C:3]1[CH:27]=[CH:26][C:6]2[CH:7]([C:17]3[C:18]([S:24][CH3:25])=[N:19][C:20](=[O:23])[NH:21][CH:22]=3)[C:8]3[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:9]=3[CH:10]=[CH:11][C:5]=2[CH:4]=1)[CH3:2].F[C:29]1[CH:34]=[CH:33][N:32]=[C:31]([N:35]([CH3:51])[CH2:36][C:37]([NH:39][C:40]2[S:41][CH:42]=[C:43]([CH2:45][C:46]([O:48][CH2:49][CH3:50])=[O:47])[N:44]=2)=[O:38])[N:30]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>CN1CCCC1=O>[CH2:1]([C:3]1[CH:27]=[CH:26][C:6]2[CH:7]([C:17]3[C:18]([S:24][CH3:25])=[N:19][C:20](=[O:23])[N:21]([C:29]4[CH:34]=[CH:33][N:32]=[C:31]([N:35]([CH3:51])[CH2:36][C:37]([NH:39][C:40]5[S:41][CH:42]=[C:43]([CH2:45][C:46]([O:48][CH2:49][CH3:50])=[O:47])[N:44]=5)=[O:38])[N:30]=4)[CH:22]=3)[C:8]3[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:9]=3[CH:10]=[CH:11][C:5]=2[CH:4]=1)[CH3:2]

参加物

5

反応物 3

HCID 10796Cesium carbonateHCID 86755657HCID 86755657、化合物HCID 178435472HCID 178435472、化合物

生成物 1

HCID 86755658HCID 86755658、化合物

試薬・触媒・溶媒 1

HCID 13387N-methyl-2-pyrrolidone溶媒

実験手順

The product of step (iv) (0.37 g), and the product of step (ii) (0.35 g) was stirred with cesium carbonate (0.32 g) in dry 1-methyl-2-pyrrolidinone (15 ml) at 65-70° C. for 20 hours. The reaction mixture was partitioned between ethyl acetate and brine. The organic layer collected, dried (MgSO4), and solvent evaporated under reduced pressure. Yield 0.61 g.

後処理

  1. customThe reaction mixture was partitioned between ethyl acetate and brine
  2. customThe organic layer collected
  3. dry with materialdried (MgSO4), and solvent
  4. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-1445cbdf53d5421b999b332b9a9d346b
出典データセット
uspto-grants-2000_08
特許番号
US06107297

反応ノート

読み込み中…