3-Methoxybenzyl chloride → 4,5-Dihydro-2-[2-[2-[3-Methoxyphenyl]ethyl]-4-methylphenyl]-4,4-dimethyloxazole

HRID 1871996

反応式

HRID 1871996 の反応式
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[C:9]1[O:10][CH2:11][C:12]([CH3:15])([CH3:14])[N:13]=1.[CH3:16][O:17][C:18]1[CH:19]=[C:20]([CH:23]=[CH:24][CH:25]=1)[CH2:21]Cl>>[CH3:16][O:17][C:18]1[CH:19]=[C:20]([CH2:21][CH2:1][C:2]2[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=2[C:9]2[O:10][CH2:11][C:12]([CH3:15])([CH3:14])[N:13]=2)[CH:23]=[CH:24][CH:25]=1

参加物

3

反応物 2

HCID 699943-Methoxybenzyl chlorideHCID 221172732-[2,4-Dimethylphenyl]-4,5-dihydro-4,4-dimethyloxazole

生成物 1

HCID 186897034,5-Dihydro-2-[2-[2-[3-Methoxyphenyl]ethyl]-4-methylphenyl]-4,4-dimethyloxazole

実験手順

The subtitle compound was prepared from the product of example 15 step (iii) (20 g) and 3-methoxybenzyl chloride (17.4 ml) by the method of example 15 step (iv). Purification was by chromatography eluting with 5-10% ethyl acetate in isohexane. Yield 20.53 g. MS: APCI(+ve): 324 (M+1).

後処理

  1. customPurification
  2. washeluting with 5-10% ethyl acetate in isohexane

出典と根拠

ORDレコード
ord-bc4350c96f7f451a94aa710a435535ca
出典データセット
uspto-grants-2000_08
特許番号
US06107297

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