HCID 15172750、化合物 → HCID 54156352、化合物
反応式
[CH3:1][O:2][CH2:3][O:4][CH:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1.[Cl:11][C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[NH:17][C:16]([C:21]([NH:23][CH:24]([CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[C:25](O)=[O:26])=[O:22])=[CH:15]2>>[CH2:28]([CH:24]([NH:23][C:21]([C:16]1[NH:17][C:18]2[C:14]([CH:15]=1)=[CH:13][C:12]([Cl:11])=[CH:20][CH:19]=2)=[O:22])[C:25]([N:8]1[CH2:9][CH2:10][CH:5]([O:4][CH2:3][O:2][CH3:1])[CH2:6][CH2:7]1)=[O:26])[C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1参加物
3
実験手順
4-Methoxymethoxy-piperidine (1.0 mmol) and 2-[(5-chloro-1H-indole-2-carbonyl)-amino]-3-phenyl-propionic acid (1.0 mmol) were coupled according to Procedure A and the product purified by chromatography on silica gel eluted with 1:1 ethyl acetate-hexanes: Yield 241 mg, 50%; HPLC (60/40) 7.67 minutes (94%);
後処理
- customthe product purified by chromatography on silica gel
- washeluted with 1:1 ethyl acetate-hexanes
- customHPLC (60/40) 7.67 minutes (94%)